GATTEX® (teduglutide)
Educational overview of a GLP-2 analog therapy used in Short Bowel Syndrome with parenteral support needs
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This page is for general education only. It is not prescribing advice, not an endorsement of any product, and not a substitute for your gastroenterologist or care team. Treatment decisions belong with you and your clinicians.
GATTEX® (teduglutide) is a prescription medicine used in adults and children 1 year of age and older with Short Bowel Syndrome (SBS) who need parenteral (IV) nutrition or fluid support. It is a manufactured form of GLP-2, a hormone involved in intestinal growth and absorption.
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GLP-2 analog Acts like natural GLP-2 to support intestinal lining growth and help the remaining bowel absorb more fluid and nutrients. |
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Daily injection Given once daily under the skin (abdomen, thigh, or upper arm) — not into muscle and not through a central line. Training is required. |
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Goal of therapy Help reduce volume, hours, or days of parenteral support when clinically appropriate — not every patient reaches full independence. |
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Regulatory note FDA-approved for adults in 2012; later expanded to children 1 year and older. Developed by NPS Pharmaceuticals; now associated with Takeda. |
Prescribing information highlights important risks. Your clinician will review whether GATTEX is appropriate and what monitoring is required.
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Abnormal cell growth / polyps May accelerate growth of abnormal cells. Adults often need colonoscopy within 6 months before starting and ongoing surveillance. |
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Bowel obstruction Intestinal blockage can occur. Report new or worsening abdominal pain, vomiting, or bloating promptly. |
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Gallbladder / pancreas Biliary and pancreatic problems (including gallstones, cholecystitis, pancreatitis) — labs are often monitored. |
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Fluid overload Swelling, higher blood pressure, or heart strain can occur as absorption improves — PN volume may need adjustment. |
Abdominal pain, nausea, injection-site reactions, flu-like symptoms, vomiting, headache, swelling of hands or feet. Pediatrics may also see upper respiratory infections and abdominal distension. Full lists are in official prescribing information.
SBSF educational booklet
GATTEX: Empowering Patients with SBS — plain-language overview of GLP-2 therapy in the context of intestinal adaptation.
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Manufacturer patient site gattex.com → |
SBSF & NPS partnership story Read article → |
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Educational booklets All booklets → |
Parenteral nutrition education Open → |
SBSF provides education so patients can ask informed questions. We do not promote or sell medications. Eligibility, dosing, monitoring, and insurance coverage are determined only by licensed clinicians and payers.