Microvillous Inclusion Disease:
Also known as Davidson’s disease, congenital microvillous atrophy and, less specifically, microvillous atrophy.
Presents as chronic, intractable diarrhea in new-born infants, starting in the first few days of life. This results in metabolic acidosis and severe dehydration. Pregnancy and birth are usually normal.
The appearance of microvillous inclusion disease on light microscopy is similar to celiac sprue; however, it usually lacks the intraepithelial lymphocytic infiltration characteristic of celiac sprue and stains positive for carcinoembryonic antigen (CEA). The definitive diagnosis is dependent on electron microscopy.
The differential diagnosis of chronic and intractable diarrhea is:
- Intestinal epithelial dysplasia
- Syndromatic diarrhea
- Immunoinflammatory enteropathy
Genetics & Prevalence
One patient, a teenage female living in Arizona, suddenly began to grow microvilli after thirteen years of TPN (Total Parenteral Nutrition) and Lipid dependancy. She now enjoys a typical teenage diet and is seen regularly by her Gastroenterologist.
One patient from the UK was documented to achieve nutritional independence at age 3.
One patient from the Netherlands was documented to be sustained by enteral nutrition rather than parenteral nutrition, but did not appear to have any MYO5B mutations.
On 26 June 2009 a six year old girl diagnosed with microvillous inclusion disease became the third person in the UK to die of swine flu.
In the past, different drugs have been tried to stop or counteract the severe diarrhea, but none of them has proven effective. Babies with microvillus inclusion disease rely on nutritionally balanced formulas given directly into the veins (intravenously) – known as total parenteral nutrition (TPN) – to get enough nourishment. TPN can help stabilize a baby’s health, but often it is not a good long-term solution. Over time, TPN may cause liver damage and increase the risk of infections. When TPN produces these kinds of complications, intestinal transplantation is often the best option.
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- ^ Arpin, M.; Crepaldi, T.; Louvard, D. (1999). “Cross-talk between Apical and Basolateral Domains of Epithelial Cells Regulates Microvillus Assembly”. In Birchmeier, Walter; Birchmeier, Carmen. Epithelial Morphogenesis in Development and Disease. Amsterdam: Harwood Academic. pp. 104. ISBN 9057024195
- ^ a b Mueller T; Hess, MW; Schiefermeier, N; Pfaller, K; Ebner, HL; Heinz-Erian, P; Ponstingl, H; Partsch, J et al. (2008). “MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity”. Nat Genet 40 (10): 1163–5. doi:10.1038/ng.225. PMID 18724368.
- ^ Kennea N, Norbury R, Anderson G, Tekay A (2001). “Congenital microvillous inclusion disease presenting as antenatal bowel obstruction”. Ultrasound Obstet Gynecol 17 (2): 172–4. doi:10.1046/j.1469-0705.2001.00211.x. PMID 11251929.
- ^ Ruemmele FM (2007). “Chronic enteropathy: molecular basis”. Nestle Nutr Workshop Ser Pediatr Program 59: 73–85; discussion 85–8. doi:10.1159/000098514.PMID 17245092.
- ^ Online ‘Mendelian Inheritance in Man’ (OMIM) Microvillous atrophy -251850
- ^ Croft NM; Howatson, AG; Ling, SC; Nairn, L; Evans, TJ; Weaver, LT (2000). “Microvillous inclusion disease: An evolving Condition”. J Pediatr Gastroenterol Nutr 32 (2): 185–189.PMID 10941974.
- ^ “Swine flu girl ‘had tough life'”. BBC News. 30 June 2009. Retrieved 12 May 2010.
- ^ Davidson GP, Cutz E, Hamilton JR, Gall DG (1978). “Familial enteropathy: a syndrome of protracted diarrhea from birth, failure to thrive, and hypoplastic villus atrophy”.Gastroenterology 75 (5): 783–90. PMID 100367.