Research & Development
Advancing science and inspiring hope for the Short Bowel Syndrome community
Contributing to Short Bowel Syndrome (SBS) research is a vital commitment to advancing science and improving lives. Whether through clinical trial participation, staying informed, or advocating for equitable care, every effort brings us closer to breakthrough treatments that redefine intestinal failure management.
How to Get Involved
Your direct participation accelerates progress in gastrointestinal medicine
Stay Informed
Follow peer-reviewed journals such as JPEN, Gastroenterology, and Clinical Nutrition.
Connect with Experts
Consult gastroenterologists and specialized GI nutritionists for clinical insights and research access.
Partner with Advocacy Groups
Join non-profits like the Short Bowel Syndrome Foundation and The Gutsy Perspective.
Educate Your Community
Share accurate, medically reviewed information and organize awareness events.
Clinical Trials Overview
Evaluating the safety, efficacy, and real-world application of novel therapies
Featured Clinical Studies
Oral Rehydration Solutions
Evaluating new ORS formulations designed to improve taste and patient fluid compliance.
Glepaglutide Efficacy & Safety
Phase III trials evaluating long-term safety, metabolic tolerance, and reduction of weekly intravenous parenteral support.
Teduglutide vs. Placebo
Investigating the GLP-2 analog’s role as an intestinotrophic growth factor to induce mucosal adaptation and tissue regeneration.
Apraglutide in Adult SBS
Assessing reductions in baseline weekly parenteral support volume compared to placebo in adults with intestinal failure.
Therapeutic Pipeline
Primary molecular targets in active development
GLP-2 Receptor Agonists
Stimulates villus growth and expands mucosal thickness to maximize absorption.
GLP-1 Receptor Agonists
Slows gastric emptying and regulates transit times for improved nutrient extraction.
CFTR Blockers
Controls cellular fluid secretion to minimize severe secretory diarrhea.
Key Research Publications & Resources
Downloadable articles and reviews
Intestinal & Multivisceral Transplantation
A thirty-year United States perspective
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A detailed, single-center analysis of clinical and technical factors
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Clinical Outcomes & Surgical Management
A retrospective cohort study of pediatric patients
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In a pediatric intestinal rehabilitation program
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Nutrition, Pharmacology & Medical Therapeutics
An exploratory cross-sectional study
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With short bowel syndrome–associated intestinal failure: A single-center experience
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Quality of Life, Psychology & Patient Advocacy
A case report
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To pediatric intestinal failure quality of life
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Related to quality of life in intestinal failure patients: A scoping review
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Of patients with intestinal failure and their caregivers
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Patient-led advocacy framework and resources
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